FL Studio is easier than Reason for sequencing as it lets you design tunes on a pattern-by-pattern basis while letting you change many patterns at the same time
I can do this in Reason.
For my computer setup I use Reason 4, Ableton 7, and Audition 3 for editing. I use Reason to come up with the patterns and beats and I import them into Ableton to set things up. Audition for clean ups. I use my usb Korg MS-20 to control my VSTs. I don't care for trackers personally. But I never got too into them.
Then I have my actual instruments to record. Couple guitars, basses, my banjo, a couple organs and lots of guitar pedals.