I was going to play a little bit longer before giving feedback, but I haven't had time to play in a couple of days so I'll just post up the notes I have so far. I got to a little bit after the part where you use the dynamite to that ammo room.
The first impression the game gives is really nice. The menu is really polished and looks and sounds really nice. The opening scene is a bit lengthy in my opinion but its not too long. The dialog could use a lot of work, like the others said, but I'm not really too good with that kind of thing so I don't really have too much advice in that department.
-I liked that you kept the training portion of the game short.
-When seeing ammo on the ground for the first time, I thought that it was some sort of hazardous spikes/rocks and jumped over it.
-There was some sort of weird message screen blip when reading the text boxes. Not sure if it was just my computer but I think you should try to fix it because it made the conversations hard to read through.
-The starting gun (semi auto rifle i think) seems way to wimpy. It was weird that I only have a limited amount of ammo with the gun and whenever I shoot it, it goes off in some random direction. It felt like I was shooting some sort of water balloon cannon or something. I could point my gun in the correct direction and not even hit the target when I'm standing almost right next to it. I guess 'aiming' wasn't one of the traits they genetically modified

. It was frustrating that I had next to no ammo with the gun and I couldn't hit anything except if I got lucky.
-The opening scene using the same portraits (though flipped) was kind of weird. Especially because one of them is the main character. Maybe redraw the head in a different position or something(even if they have the same face) to more easily tell who is speaking.
-The enemy design wasn't that great. I think the only enemies I fought were the cockroaches and mutant things, but they had pretty much the same AI. Whenever they detected you they relentlessly followed you at a speed that almost matched your own. The movements didn't really seem organic, not to mention fairly difficult for the very first part of the game. It was very difficult to kill them without taking very much damage. It's hard to believe that I am going to assassinate some super villan guy whenever my guy has trouble killing a cockroach.
-The mutant enemy looks too much like a human/friendly character and I ran into him on purpose the first time I encountered one. He wasn't attacking me so I thought he was not an enemy.
-This is pretty much only a problem because of the limited ammo, but I kept pressing the shoot button when I was looking for jump and wasted some ammo. I would suggest redefinable keys, as I would for any game really.)
-As I said above, I thought that the menu and hud seemed really polished which gives the game a feeling of completeness.
-I really liked the graphics and the music and the general atmosphere the game provided.
-The landscape seemed a bit repetative without anything too new or different to look forward to between screens. Maybe adding in some unique tiles or landmarks in some areas to mix it up a bit might help.
Overall I thought it was a really good work in progress. I'll play through the rest of the game when I get a chance and let you know what I think. I'm really interested in seeing this game develop. Good work so far!
