I was thinking of trying a drawn art style instead of pixel art, like this game Neverending Nightmares:
http://store.steampowered.com/app/253330/I've only created pixel art games before which use a small resolution and is then blown up, but I'm guessing this would look awful for non-pixel games.
So what resolution should I be targeting? For example, should I be setting the game's resolution to 1280x720 and hope the user puts it into fullscreen mode?
Also what resolution for the art work? I suspect the best approach would be draw it at double the size you intend it be to be in-game, then draw it at 50% in-game? I'm a little worried this might impact performance though for low-end PCs.