It's not hard to pick up (tap a few cards, something happens and then you start noticing patterns, etc), but it seems nearly impossible to match anything that isn't getting...whatever the equivalent of "meh" was as a ranking without knowing what you're doing, and I was having issues gleaning exactly what I was doing from just playing it.
Hey Johnki, thanks for the response. That's probably the largest issue people have been having with the game, that it's hard to just pick up and play. Like I said, for the update there will be a much more helpful "help" section as well as an easy mode.
If you want to learn more, the rules are based off of a game developed by a geneticist in the 1970's. You can read about it here:
Set Game