Hate the antagonist

BIOSHOCK SPOILERZ!

I think the only antagonist gaming wise were the antagonists of both Bioshock games. Not Ryan, but rather Fontaine in the original. I think it's because it felt like he had tricked me, and as the game wants you to it felt like I'd been manipulated all along (as was obviously in keeping with the main theme of choice in Bioshock.) I also felt angry at him because in a way Ryan had a great idea and just wanted to make something he felt was better than the surface world, and Fontaine saw the flaws in it and tore it down. (Of course the problem was that his libertarian utopia was an impossible concept and Ryan had failed to account for a whole host of flaws, but initially I felt angry at Fontaine for destroying it just for his own gain)

I hated Lamb because she is basically everything I am against, and her whole thing of deindividualising people, brainwashing, controlling people through 'socialism' and basically enslaving the desperate people of rapture was pretty disgusting. I spent the whole game wanting to kill that condescending bitch. Also again the notion of control that it felt like she was exerting over Delta due to her having his Little Sister was another form of frustrating manipulation.

Essentially a good way for an antagonist to seem really hateable to me is if they're manipulative, controlling, and use people for their own ends. A lot of soaps have villains that are truly hateworthy due to their domestic abuse methods, which entails a whole lot of this. It's also much more believable and relatable than say some guy who blows up dogs for fun or something, which while awful isn't really as easy to identify with.